Seroatlas · Human Serome Atlas

DNAJC4

DnaJ homolog subfamily C member 4

Also known as: DNJC4_HUMAN, HSPF2, MCG18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NNZ3
Gene: DNAJC4
Ensembl: ENSG00000110011
Chromosome: 11
Canonical length: 241 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding and response to unfolded protein. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q9NNZ3|DNAJC4
     1  MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE
    61  LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT
   121  HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ
   181  MHLNFMDEKD RIITAFYNEA RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG
   241  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 232 nTPM

Expression across tissuesHPA

Tissue

testis: 232 nTPM
pancreas: 98 nTPM
heart muscle: 92 nTPM
adrenal gland: 83 nTPM
kidney: 77 nTPM
liver: 74 nTPM

Single-cell type

late spermatids: 6,444 nCPM
early spermatids: 743 nCPM
late primary spermatocytes: 184 nCPM
parietal cells: 133 nCPM
epididymal principal cells: 132 nCPM
breast secretory cells: 119 nCPM

Immune cell

plasmacytoid DC: 134 nTPM
myeloid DC: 83 nTPM
classical monocyte: 60 nTPM
intermediate monocyte: 55 nTPM
naive B-cell: 52 nTPM
memory B-cell: 52 nTPM

Brain region

thalamus: 52 nTPM
choroid plexus: 52 nTPM
pons: 48 nTPM
medulla oblongata: 47 nTPM
midbrain: 44 nTPM
hypothalamus: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

unfolded protein binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

DnaJ domain
Chaperone J-domain superfamily
DnaJ domain
DnaJ Homolog Subfamily C Member 4

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC4 as an antibody target. Whether an autoantibody or antibody against DNAJC4 could matter depends on whether native DNAJC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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