DNAJC28

Protein identityUniProt · HPA

UniProt accession

Q9NX36

Gene

DNAJC28

Ensembl

ENSG00000177692

Chromosome

21

Canonical length

388 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a member of the DnaJ heat shock protein family. The encoded protein, which contains a conserved N-terminal DnaJ domain, is thought to play a role in protein folding or act as a molecular chaperone protein. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q9NX36|DNAJC28
     1  MNTMYVMMAQ ILRSHLIKAT VIPNRVKMLP YFGIIRNRMM STHKSKKKIR EYYRLLNVEE
    61  GCSADEVRES FHKLAKQYHP DSGSNTADSA TFIRIEKAYR KVLSHVIEQT NASQSKGEEE
   121  EDVEKFKYKT PQHRHYLSFE GIGFGTPTQR EKHYRQFRAD RAAEQVMEYQ KQKLQSQYFP
   181  DSVIVKNIRQ SKQQKITQAI ERLVEDLIQE SMAKGDFDNL SGKGKPLKKF SDCSYIDPMT
   241  HNLNRILIDN GYQPEWILKQ KEISDTIEQL REAILVSRKK LGNPMTPTEK KQWNHVCEQF
   301  QENIRKLNKR INDFNLIVPI LTRQKVHFDA QKEIVRAQKI YETLIKTKEV TDRNPNNLDQ
   361  GEGEKTPEIK KGFLNWMNLW KFIKIRSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

6.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.39

gnomAD pLI

0

gnomAD missense Z

0.02

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

• DnaJ domain
• Chaperone J-domain superfamily
• DnaJ domain
• DnaJ homologue, subfamily C, member 28, conserved domain
• DnaJ homolog subfamily C member 28
• DnaJ homologue, subfamily C, member 28, conserved domain

KeywordsUniProt

• Chaperone
• Coiled coil
• Phosphoprotein