Seroatlas · Human Serome Atlas

DNAJC22

DnaJ homolog subfamily C member 22

Also known as: DJC22_HUMAN, FLJ13236, wus

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4W6
Gene: DNAJC22
Ensembl: ENSG00000178401
Chromosome: 12
Canonical length: 341 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q8N4W6|DNAJC22
     1  MAKGLLVTYA LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW KLPSFVAQAN
    61  RAQGQRQSPR GVTPPLSPIR FAAQVIVGIY FGLVALISLS SMVNFYIVAL PLAVGLGVLL
   121  VAAVGNQTSD FKNTLGSAFL TSPIFYGRPI AILPISVAAS ITAQRHRRYK ALVASEPLSV
   181  RLYRLGLAYL AFTGPLAYSA LCNTAATLSY VAETFGSFLN WFSFFPLLGR LMEFVLLLPY
   241  RIWRLLMGET GFNSSCFQEW AKLYEFVHSF QDEKRQLAYQ VLGLSEGATN EEIHRSYQEL
   301  VKVWHPDHNL DQTEEAQRHF LEIQAAYEVL SQPRKPWGSR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

liver: 17 nTPM
duodenum: 5.3 nTPM
thyroid gland: 4.1 nTPM
small intestine: 3.8 nTPM
gallbladder: 2.8 nTPM
kidney: 2.6 nTPM

Single-cell type

hepatocytes: 84 nCPM
enterocytes: 67 nCPM
cholangiocytes: 58 nCPM
colonocytes: 44 nCPM
goblet cells: 44 nCPM
epididymal efferent duct absorptive cells: 42 nCPM

Immune cell

neutrophil: 0.3 nTPM
gdT-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 5.3 nTPM
pons: 5.3 nTPM
cerebellum: 4.8 nTPM
midbrain: 4.1 nTPM
white matter: 3.8 nTPM
cerebral cortex: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC22 as an antibody target. Whether an autoantibody or antibody against DNAJC22 could matter depends on whether native DNAJC22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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