Seroatlas · Human Serome Atlas

DNAJC15

DnaJ homolog subfamily C member 15

Also known as: DJC15_HUMAN, DNAJD1, MCJ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5T4
Gene: DNAJC15
Ensembl: ENSG00000120675
Chromosome: 13
Canonical length: 150 aa
Protein class: Disease related genes, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>Q9Y5T4|DNAJC15
     1  MAARGVIAPV GESLRYAEYL QPSAKRPDAD VDQQRLVRSL IAVGLGVAAL AFAGRYAFRI
    61  WKPLEQVITE TAKKISTPSF SSYYKGGFEQ KMSRREAGLI LGVSPSAGKA KIRTAHRRVM
   121  ILNHPDKGGS PYVAAKINEA KDLLETTTKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 21 nTPM
midbrain: 14 nTPM
amygdala: 11 nTPM
hypothalamus: 11 nTPM
hippocampal formation: 11 nTPM
basal ganglia: 10 nTPM

Single-cell type

late primary spermatocytes: 732 nCPM
extravillous trophoblasts: 438 nCPM
early spermatids: 438 nCPM
gastric progenitor cells: 437 nCPM
endometrial glandular cells: 387 nCPM
oocytes: 350 nCPM

Immune cell

myeloid DC: 8.2 nTPM
basophil: 5.8 nTPM
memory B-cell: 5.7 nTPM
plasmacytoid DC: 5.2 nTPM
T-reg: 5 nTPM
intermediate monocyte: 4.9 nTPM

Brain region

spinal cord: 23 nTPM
thalamus: 21 nTPM
white matter: 20 nTPM
hypothalamus: 19 nTPM
medulla oblongata: 18 nTPM
pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: -0.42
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PAM16

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC15 as an antibody target. Whether an autoantibody or antibody against DNAJC15 could matter depends on whether native DNAJC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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