Seroatlas · Human Serome Atlas

DNAJC14

DnaJ homolog subfamily C member 14

Also known as: DJC14_HUMAN, DNAJ, DRIP78, FLJ32792, HDJ3, LIP6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6Y2X3
Gene: DNAJC14
Ensembl: ENSG00000135392
Chromosome: 12
Canonical length: 702 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable dopamine receptor binding activity. Predicted to be involved in protein transport. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

702 residues, UniProt reviewed canonical sequence.

>Q6Y2X3|DNAJC14
     1  MAQKHPGERG LYGAHHSGGA SLRTLGPSVD PEIPSFSGLR DSAGTAPNGT RCLTEHSGPK
    61  HTQHPNPAHW LDPSHGPPGG PGPPRDAEDP DQSETSSEEE SGVDQELSKE NETGNQKDGN
   121  SFLSIPSACN CQGTPGIPEG PYSEGGNGSS SNFCHHCTSP ALGEDELEEE YDDEESLKFP
   181  SDFSRVSSGK KPPSRRQRHR FPTKEDTREG GRRDPRSPGR HRLGRKRSQA DKRKGLGLWG
   241  AEELCQLGQA GFWWLIELLV LVGEYVETCG HLIYACRQLK SSDLDLFRVW MGVWTGRLGG
   301  WAQVMFQFLS QGFYCGVGLF TRFLKLLGAL LLLALALFLG FLQLGWRFLV GLGDRLGWRD
   361  KATWLFSWLD SPALQRCLTL LRDSRPWQRL VRIVQWGWLE LPWVKQNINR QGNAPVASGR
   421  YCQPEEEVAR LLTMAGVPED ELNPFHVLGV EATASDVELK KAYRQLAVMV HPDKNHHPRA
   481  EEAFKVLRAA WDIVSNAEKR KEYEMKRMAE NELSRSVNEF LSKLQDDLKE AMNTMMCSRC
   541  QGKHRRFEMD REPKSARYCA ECNRLHPAEE GDFWAESSML GLKITYFALM DGKVYDITEW
   601  AGCQRVGISP DTHRVPYHIS FGSRIPGTRG RQRATPDAPP ADLQDFLSRI FQVPPGQMPN
   661  GNFFAAPQPA PGAAAASKPN STVPKGEAKP KRRKKVRRPF QR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 23 nTPM
thymus: 22 nTPM
tonsil: 18 nTPM
testis: 17 nTPM
spleen: 17 nTPM
thyroid gland: 17 nTPM

Single-cell type

epicardial cells: 48 nCPM
adipocytes: 45 nCPM
cardiomyocytes: 22 nCPM
retinal pigment epithelial cells: 8.5 nCPM
megakaryocytes: 6.2 nCPM
late spermatids: 5.1 nCPM

Immune cell

eosinophil: 16 nTPM
basophil: 15 nTPM
gdT-cell: 13 nTPM
memory CD8 T-cell: 12 nTPM
non-classical monocyte: 12 nTPM
plasmacytoid DC: 12 nTPM

Brain region

white matter: 23 nTPM
basal ganglia: 21 nTPM
thalamus: 21 nTPM
medulla oblongata: 21 nTPM
midbrain: 21 nTPM
cerebral cortex: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.09
gnomAD pLI: 1
gnomAD missense Z: 1.57
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein transport

Molecular functions

dopamine receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

DnaJ domain
Chaperone J-domain superfamily
DnaJ domain
Cleavage inducing molecular chaperone, Jiv
Viral replication and host interaction regulator
Cleavage inducing molecular chaperone

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DRD1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC14 as an antibody target. Whether an autoantibody or antibody against DNAJC14 could matter depends on whether native DNAJC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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