Seroatlas · Human Serome Atlas

DNAI7

Dynein axonemal intermediate chain 7

Also known as: CASC1, CFAP94, DNAI7_HUMAN, FLJ10921, LAS1, PPP1R54

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6TDU7
Gene
DNAI7
Ensembl
ENSG00000118307
Chromosome
12
Canonical length
716 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable beta-tubulin binding activity and microtubule binding activity. Predicted to be located in cilium and microtubule cytoskeleton. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme and cytoplasmic microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

716 residues, UniProt reviewed canonical sequence.

>Q6TDU7|DNAI7
     1  MSGSKKKKVT KAERLKLLQE EEERRLKEEE EARLKYEKEE MERLEIQRIE KEKWHRLEAK
    61  DLERRNEELE ELYLLERCFP EAEKLKQETK LLSQWKHYIQ CDGSPDPSVA QEMNTFISLW
   121  KEKTNETFEE VIEKSKVVLN LIEKLKFILL ETPPCDLQDK NIIQYQESIL QLQELLHLKF
   181  GVATEILLKQ ASTLADLDSG NMEKVIKDEN VTLYVWANLK KNPRHRSVRF SETQIGFEIP
   241  RILATSDIAV RLLHTHYDHV SALHPVSTPS KEYTSAVTEL VKDDVKNVEK AISKEVEEES
   301  KQQERGSHLI QEEEIKVEEE QGDIEVKMSS AEEESEAIKC EREMKVLSET VSAAQLLLVE
   361  NSSEKPDFFE DNVVDLCQFT TLGGVYHLDI LELPPQCKPV KGWMIVEILK EGLQKYTYPP
   421  ETTEEFETEN AFPPIEVTLE VHENVIFFED PVVVRWDAEG KHWRTDGISN VSYKPKERLV
   481  TFSLDTFGPV TLIQDAHINM PYQSWELRPL DVNKVLLTVT TVFTEIQIQI KENLCMLSSI
   541  KLKDKKHISI LEGTWMTPIP FIIALKEAGL NIFPTRHSHF YVIINNKVPL VEVKAYRQMA
   601  LLSSAFAFGW SKWNLLCNST KVVFKVREHL TEACTENPNW ALLMFSGDRA QRLKIKEESE
   661  AFSEALKEET EFHSTLYHMV KDFASEEAME KVRSSNCQFV NSVCHMLLST RLLSYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAI7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • testis: 21 nTPM
  • choroid plexus: 14 nTPM
  • fallopian tube: 13 nTPM
  • epididymis: 5.6 nTPM
  • retina: 4.7 nTPM
  • pituitary gland: 4.1 nTPM

Single-cell type

  • ependymal cells: 589 nCPM
  • respiratory ciliated cells: 504 nCPM
  • early spermatids: 373 nCPM
  • choroid plexus epithelial cells: 356 nCPM
  • fallopian tube ciliated cells: 349 nCPM
  • late primary spermatocytes: 316 nCPM

Immune cell

  • neutrophil: 1.4 nTPM
  • naive B-cell: 1 nTPM
  • memory B-cell: 0.7 nTPM
  • basophil: 0.4 nTPM
  • NK-cell: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM

Brain region

  • choroid plexus: 31 nTPM
  • medulla oblongata: 18 nTPM
  • midbrain: 18 nTPM
  • spinal cord: 14 nTPM
  • hypothalamus: 11 nTPM
  • pons: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • CASC1, C-terminal
  • Dynein-f, intermediate chain IC97/Dnai7-like
  • IC97/Casc1, N-terminal
  • Cancer susceptibility candidate 1 C-terminal
  • Cancer susceptibility candidate 1 N-terminus

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAI7 as an antibody target. Whether an autoantibody or antibody against DNAI7 could matter depends on whether native DNAI7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAI7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAI7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAI7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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