DNAH10OS
Uncharacterized protein DNAH10OS
Also known as: D10OS_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for DNAH10OS in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
163 residues, UniProt reviewed canonical sequence.
>P0CZ25|DNAH10OS
1 MHSLPRSGSI RRTHSDTQAT GWPPPQRIGD SPGPSPAFLS CPPSLCGGAA QTGDPVALPH
61 GPEKWVWGGG LSPRNPHSWG IKAHGLRPPW APRLERCMVP ESEWAPWQPQ LPCEPKWLGS
121 RKSKPHRESG LRGGGPSRCA KRGTHSCGPR ESGGPDTCHL PCHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DNAH10OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.72
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.11
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DNAH10OS as an antibody target. Whether an autoantibody or antibody against DNAH10OS could matter depends on whether native DNAH10OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DNAH10OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DNAH10OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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