Seroatlas · Human Serome Atlas

DMKN

Dermokine

Also known as: DMKN_HUMAN, ZD52F10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6E0U4
Gene
DMKN
Ensembl
ENSG00000161249
Chromosome
19
Canonical length
476 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Nucleoplasm,Cytosol
Secretome location
Secreted in other tissues
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q6E0U4|DMKN
     1  MKFQGPLACL LLALCLGSGE AGPLQSGEES TGTNIGEALG HGLGDALSEG VGKAIGKEAG
    61  GAAGSKVSEA LGQGTREAVG TGVRQVPGFG VADALGNRVG EAAHALGNTG HEIGRQAEDV
   121  IRHGADAVRG SWQGVPGHNG AWETSGGHGI FGSQGGLGGQ GQGNPGGLGT PWVHGYPGNS
   181  AGSFGMNPQG APWGQGGNGG PPNFGTNTQG AVAQPGYGSV RASNQNEGCT NPPPSGSGGG
   241  SSNSGGGSGS QSGSSGSGSN GDNNNGSSSG GSSSGSSSGG SSGGSSGGSS GNSGGSRGDS
   301  GSESSWGSST GSSSGNHGGS GGGNGHKPGC EKPGNEARGS GESGIQNSET SPGMFNFDTF
   361  WKNFKSKLGF INWDAINKNQ VPPPSTRALL YFSRLWEDFK QNTPFLNWKA IIEGADASSL
   421  QKRAGRDDQN YNYNQHAYPT AYGGKYSVKT PAKGGVSPSS SASRVQPGLL QWVKFW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMKN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
4,625 nTPM

Expression across tissuesHPA

Tissue

  • skin: 4,625 nTPM
  • vagina: 346 nTPM
  • cervix: 343 nTPM
  • esophagus: 209 nTPM
  • breast: 183 nTPM
  • parathyroid gland: 82 nTPM

Single-cell type

  • suprabasal keratinocytes: 5,448 nCPM
  • esophageal apical cells: 1,448 nCPM
  • epididymal efferent duct absorptive cells: 832 nCPM
  • basal keratinocytes: 672 nCPM
  • esophageal suprabasal cells: 482 nCPM
  • fallopian tube ciliated cells: 351 nCPM

Immune cell

  • NK-cell: 12 nTPM
  • gdT-cell: 6.4 nTPM
  • MAIT T-cell: 5.5 nTPM
  • memory CD8 T-cell: 3.1 nTPM
  • naive CD8 T-cell: 2 nTPM
  • memory B-cell: 1.7 nTPM

Brain region

  • pons: 29 nTPM
  • choroid plexus: 25 nTPM
  • medulla oblongata: 17 nTPM
  • basal ganglia: 15 nTPM
  • midbrain: 5.9 nTPM
  • cerebellum: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Dermokine

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMKN as an antibody target. Whether an autoantibody or antibody against DMKN could matter depends on whether native DMKN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMKN is annotated as secreted, so native DMKN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DMKN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DMKN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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