DMAC2L
ATP synthase subunit s, mitochondrial
Also known as: ATP5S, ATP5S_HUMAN, ATPW, HSU79253
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99766
- Gene
- DMAC2L
- Ensembl
- ENSG00000125375
- Chromosome
- 14
- Canonical length
- 200 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Mitochondria
- Quaternary structure
- Homotetramer
OverviewNCBI Gene
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
200 residues, UniProt reviewed canonical sequence.
>Q99766|DMAC2L
1 MMPFGKISQQ LCGVKKLPWS CDSRYFWGWL NAVFNKVDYD RIRDVGPDRA ASEWLLRCGA
61 MVRYHGQERW QKDYNHLPTG PLDKYKIQAI DATDSCIMSI GFDHMEGLEH VEKIRLCKCH
121 YIEDDCLLRL SQLENLQKTI LEMEIISCGN ITDKGIIALR HLRNLKYLLL SDLPGVREKE
181 NLVQAFKTAL PSLELKLQLKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DMAC2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 21 nTPM
- testis: 20 nTPM
- tongue: 17 nTPM
- heart muscle: 14 nTPM
- thyroid gland: 14 nTPM
- bone marrow: 13 nTPM
Single-cell type
- early spermatids: 312 nCPM
- late primary spermatocytes: 242 nCPM
- late spermatids: 191 nCPM
- platelets: 146 nCPM
- esophageal apical cells: 105 nCPM
- oocytes: 74 nCPM
Immune cell
- basophil: 24 nTPM
- non-classical monocyte: 20 nTPM
- eosinophil: 19 nTPM
- memory B-cell: 18 nTPM
- plasmacytoid DC: 18 nTPM
- naive B-cell: 17 nTPM
Brain region
- white matter: 36 nTPM
- basal ganglia: 28 nTPM
- medulla oblongata: 28 nTPM
- cerebral cortex: 25 nTPM
- pons: 25 nTPM
- midbrain: 25 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.39
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DMAC2L as an antibody target. Whether an autoantibody or antibody against DMAC2L could matter depends on whether native DMAC2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DMAC2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DMAC2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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