Seroatlas · Human Serome Atlas

DMAC2

Distal membrane-arm assembly complex protein 2

Also known as: ATP5SL, DMAC2_HUMAN, FLJ10241

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NW81
Gene: DMAC2
Ensembl: ENSG00000105341
Chromosome: 19
Canonical length: 257 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q9NW81|DMAC2
     1  MAAPWASLRL VAPMWNGRIR GIHRLGAAVA PEGNQKKKRT ILQFLTNYFY DVEALRDYLL
    61  QREMYKVHEK NRSYTWLEKQ HGPYGAGAFF ILKQGGAVKF RDKEWIRPDK YGHFSQEFWN
   121  FCEVPVEAVD AGDCDINYEG LDNLLRLKEL QSLSLQRCCH VDDWCLSRLY PLADSLQELS
   181  LAGCPRISER GLACLHHLQN LRRLDISDLP AVSNPGLTQI LVEEMLPNCE VVGVDWAEGL
   241  KSGPEEQPRD TASPVPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMAC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 105 nTPM
tongue: 75 nTPM
skeletal muscle: 64 nTPM
kidney: 44 nTPM
duodenum: 42 nTPM
small intestine: 40 nTPM

Single-cell type

enterocytes: 95 nCPM
extravillous trophoblasts: 81 nCPM
esophageal basal cells: 78 nCPM
migrating cytotrophoblasts: 67 nCPM
esophageal suprabasal cells: 58 nCPM
hofbauer cells: 57 nCPM

Immune cell

myeloid DC: 40 nTPM
classical monocyte: 28 nTPM
plasmacytoid DC: 27 nTPM
intermediate monocyte: 26 nTPM
eosinophil: 24 nTPM
total PBMC: 23 nTPM

Brain region

thalamus: 29 nTPM
midbrain: 29 nTPM
medulla oblongata: 29 nTPM
pons: 28 nTPM
hypothalamus: 27 nTPM
cerebellum: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat domain superfamily

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMAC2 as an antibody target. Whether an autoantibody or antibody against DMAC2 could matter depends on whether native DMAC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMAC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DMAC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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