Seroatlas · Human Serome Atlas

DMAC1

Distal membrane-arm assembly complex protein 1

Also known as: C9orf123, DMAC1_HUMAN, MGC4730, TMEM261

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GE9
Gene: DMAC1
Ensembl: ENSG00000137038
Chromosome: 9
Canonical length: 116 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>Q96GE9|DMAC1
     1  MGSRLSQPFE SYITAPPGTA AAPAKPAPPA TPGAPTSPAE HRLLKTCWSC RVLSGLGLMG
    61  AGGYVYWVAR KPMKMGYPPS PWTITQMVIG LSENQGIATW GIVVMADPKG KAYRVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 40 nTPM
tongue: 28 nTPM
heart muscle: 27 nTPM
parathyroid gland: 21 nTPM
thymus: 19 nTPM
kidney: 18 nTPM

Single-cell type

hofbauer cells: 381 nCPM
parietal cells: 230 nCPM
gastric progenitor cells: 215 nCPM
esophageal basal cells: 208 nCPM
enteric transient amplifying cells: 204 nCPM
esophageal suprabasal cells: 187 nCPM

Immune cell

memory B-cell: 27 nTPM
naive B-cell: 23 nTPM
NK-cell: 21 nTPM
naive CD4 T-cell: 21 nTPM
T-reg: 20 nTPM
total PBMC: 20 nTPM

Brain region

cerebral cortex: 36 nTPM
hypothalamus: 30 nTPM
cerebellum: 29 nTPM
basal ganglia: 27 nTPM
white matter: 27 nTPM
hippocampal formation: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.01
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial respiratory chain complex I assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

Distal membrane-arm assembly complex protein 1-like domain
Distal Membrane-arm Assembly Complex Protein
DMAC1/Dmo2-like domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMAC1 as an antibody target. Whether an autoantibody or antibody against DMAC1 could matter depends on whether native DMAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMAC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DMAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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