Seroatlas · Human Serome Atlas

DLX6

Homeobox protein DLX-6

Also known as: DLX6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P56179
Gene: DLX6
Ensembl: ENSG00000006377
Chromosome: 7
Canonical length: 175 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies

OverviewNCBI Gene

This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

175 residues, UniProt reviewed canonical sequence.

>P56179|DLX6
     1  MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR KPRTIYSSLQ
    61  LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK RSKFKKLLKQ GSNPHESDPL
   121  QGSAALSPRS PALPPVWDVS ASAKGVSMPP NSYMPGYSHW YSSPHQDTMQ RPQMM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLX6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 10 nTPM
testis: 5.2 nTPM
hypothalamus: 3.6 nTPM
placenta: 2.8 nTPM
endometrium: 2.4 nTPM
cervix: 1.9 nTPM

Single-cell type

extravillous trophoblasts: 97 nCPM
oocytes: 65 nCPM
migrating cytotrophoblasts: 45 nCPM
cytotrophoblasts: 38 nCPM
endometrial luminal cells: 38 nCPM
endometrial ciliated cells: 34 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 17 nTPM
hypothalamus: 12 nTPM
cerebral cortex: 7.6 nTPM
amygdala: 5.1 nTPM
thalamus: 3.4 nTPM
hippocampal formation: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 1.17
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLX6 as an antibody target. Whether an autoantibody or antibody against DLX6 could matter depends on whether native DLX6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLX6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DLX6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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