Seroatlas · Human Serome Atlas

DLEU7

Leukemia-associated protein 7

Also known as: FLJ44882, LEU7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UYE1
Gene: DLEU7
Ensembl: ENSG00000186047
Chromosome: 13
Canonical length: 221 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for DLEU7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q6UYE1|DLEU7
     1  MASPAPLVAS ISHQMVALQT LQLLQQEWGW GDGPVAPGNP RDPDHVSTAP ARRSGPPRAR
    61  PGPGREERGG GVGTRSRRTA ARANSPEEEV VRGAEGGAEL LPFPRDRGPC TLAQMAMRSA
   121  LARVVDSTSE LVSVEQTLLG PLQQERSFPI HLKDSVEFRN ICSHLALQIE GQQFDRDLNA
   181  AHQCLKTIVK KLIQSLANFP SDAHMVACAS LRQILQNLPD I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLEU7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 5.2 nTPM
cerebellum: 3.8 nTPM
hypothalamus: 3.5 nTPM
basal ganglia: 3.2 nTPM
amygdala: 3 nTPM
hippocampal formation: 2.8 nTPM

Single-cell type

microglia: 277 nCPM
kupffer cells: 98 nCPM
brain inhibitory neurons: 57 nCPM
oligodendrocyte progenitor cells: 47 nCPM
early spermatids: 46 nCPM
brain excitatory neurons: 41 nCPM

Immune cell

intermediate monocyte: 0.2 nTPM
neutrophil: 0.2 nTPM
T-reg: 0.2 nTPM
total PBMC: 0.2 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

white matter: 7 nTPM
thalamus: 6.9 nTPM
cerebral cortex: 5.7 nTPM
midbrain: 5.7 nTPM
basal ganglia: 5.4 nTPM
medulla oblongata: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0.18
gnomAD missense Z: 0.73
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Leukemia-associated protein 7
Leukemia-associated protein 7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLEU7 as an antibody target. Whether an autoantibody or antibody against DLEU7 could matter depends on whether native DLEU7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLEU7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DLEU7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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