Seroatlas · Human Serome Atlas

DLEU1

Leukemia-associated protein 1

Also known as: LEU1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43261
Gene: DLEU1
Canonical length: 78 aa

OverviewNCBI Gene

No narrative summary is available for DLEU1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

78 residues, UniProt reviewed canonical sequence.

>O43261|DLEU1
     1  MRPCIWIHVH LKPPCRLVEL LPFSSALQGL SHLSLGTTLP VILPERNEEQ NLQELSHNAD
    61  KYQMGDCCKE EIDDSIFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DLEU1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0.47
gnomAD missense Z: 0.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

KeywordsUniProt

Tumor suppressor

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DLEU1 as an antibody target. Whether an autoantibody or antibody against DLEU1 could matter depends on whether native DLEU1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DLEU1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DLEU1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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