Seroatlas · Human Serome Atlas

DKKL1

Dickkopf-like protein 1

Also known as: CT34, DKKL1_HUMAN, SGY-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UK85
Gene
DKKL1
Ensembl
ENSG00000104901
Chromosome
19
Canonical length
242 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Vesicles,Acrosome,Equatorial segment,Mid piece
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q9UK85|DKKL1
     1  MGEASPPAPA RRHLLVLLLL LSTLVIPSAA APIHDADAQE SSLGLTGLQS LLQGFSRLFL
    61  KGNLLRGIDS LFSAPMDFRG LPGNYHKEEN QEHQLGNNTL SSHLQIDKMT DNKTGEVLIS
   121  ENVVASIQPA EGSFEGDLKV PRMEEKEALV PIQKATDSFH TELHPRVAFW IIKLPRRRSH
   181  QDALEGGHWL SEKRHRLQAI RDGLRKGTHK DVLEEGTESS SHSRLSPRKT HLLYILRPSR
   241  QL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DKKL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
352 nTPM

Expression across tissuesHPA

Tissue

  • testis: 352 nTPM
  • fallopian tube: 1.1 nTPM
  • endometrium: 1 nTPM
  • ovary: 1 nTPM
  • pancreas: 0.9 nTPM
  • salivary gland: 0.9 nTPM

Single-cell type

  • late spermatids: 3,112 nCPM
  • early spermatids: 2,508 nCPM
  • late primary spermatocytes: 1,665 nCPM
  • early primary spermatocytes: 21 nCPM
  • sertoli cells: 19 nCPM
  • tuft cells: 12 nCPM

Immune cell

  • memory B-cell: 1.7 nTPM
  • naive B-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 0.8 nTPM
  • medulla oblongata: 0.8 nTPM
  • midbrain: 0.6 nTPM
  • white matter: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • basal ganglia: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
-0.16
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DKKL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • SLXL1
  • SLY

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DKKL1 as an antibody target. Whether an autoantibody or antibody against DKKL1 could matter depends on whether native DKKL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DKKL1 is annotated as secreted, so native DKKL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DKKL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DKKL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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