DKK4

Protein identityUniProt · HPA

UniProt accession

Q9UBT3

Gene

DKK4

Ensembl

ENSG00000104371

Chromosome

8

Canonical length

224 aa

Protein class

Predicted secreted proteins

Secretome location

Secreted in other tissues

OverviewNCBI Gene

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q9UBT3|DKK4
     1  MVAAVLLGLS WLCSPLGALV LDFNNIRSSA DLHGARKGSQ CLSDTDCNTR KFCLQPRDEK
    61  PFCATCRGLR RRCQRDAMCC PGTLCVNDVC TTMEDATPIL ERQLDEQDGT HAEGTTGHPV
   121  QENQPKRKPS IKKSQGRKGQ EGESCLRTFD CGPGLCCARH FWTKICKPVL LEGQVCSRRG
   181  HKDTAQAPEI FQRCDCGPGL LCRSQLTSNR QHARLRVCQK IEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DKK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

4.6 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.25

gnomAD pLI

0

gnomAD missense Z

0.23

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of canonical Wnt signaling pathway
• negative regulation of Wnt signaling pathway
• Wnt signaling pathway
• negative regulation of hair follicle placode formation

Molecular functions

• co-receptor binding
• receptor antagonist activity

Cellular components

• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Dickkopf, N-terminal cysteine-rich
• Dickkopf related protein 1-4
• Dickkopf-related protein 1/2/4, C-terminal subdomain 2
• Dickkopf-related protein 1/2/4, C-terminal subdomain 1
• Dickkopf N-terminal cysteine-rich region
• Dickkopf-related protein 1/2/4, C-terminal subdomain 2
• Dickkopf-related protein 1/2/4, C-terminal subdomain 1
• Dickkopf-related protein 4, second cysteine-rich domain

KeywordsUniProt

• Cleavage on pair of basic residues
• Developmental protein
• Disulfide bond
• Secreted
• Signal
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of DKK4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LRP5
• LRP6