DKK3

Protein identityUniProt · HPA

UniProt accession

Q9UBP4

Gene

DKK3

Ensembl

ENSG00000050165

Chromosome

11

Canonical length

350 aa

Protein class

Plasma proteins, Predicted secreted proteins

Subcellular location

Nuclear bodies,Vesicles,Cytosol

Secretome location

Secreted in other tissues

OverviewNCBI Gene

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9UBP4|DKK3
     1  MQRLGATLLC LLLAAAVPTA PAPAPTATSA PVKPGPALSY PQEEATLNEM FREVEELMED
    61  TQHKLRSAVE EMEAEEAAAK ASSEVNLANL PPSYHNETNT DTKVGNNTIH VHREIHKITN
   121  NQTGQMVFSE TVITSVGDEE GRRSHECIID EDCGPSMYCQ FASFQYTCQP CRGQRMLCTR
   181  DSECCGDQLC VWGHCTKMAT RGSNGTICDN QRDCQPGLCC AFQRGLLFPV CTPLPVEGEL
   241  CHDPASRLLD LITWELEPDG ALDRCPCASG LLCQPHSHSL VYVCKPTFVG SRDQDGEILL
   301  PREVPDEYEV GSFMEEVRQE LEDLERSLTE EMALREPAAA AAALLGGEEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DKK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

1,240 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DKK3.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Autosomal dominant polycystic liver disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.05

gnomAD pLI

0

gnomAD missense Z

0.8

DepMap mean gene effect

-0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adrenal gland development
• anatomical structure morphogenesis
• negative regulation of aldosterone biosynthetic process
• negative regulation of canonical Wnt signaling pathway
• negative regulation of cortisol biosynthetic process
• negative regulation of DNA-templated transcription
• regulation of transforming growth factor beta receptor signaling pathway
• Wnt signaling pathway
• negative regulation of anti-Mullerian hormone signaling pathway

Molecular functions

• co-receptor binding
• receptor antagonist activity

Cellular components

• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Dickkopf, N-terminal cysteine-rich
• Dickkopf related protein 1-4
• Dickkopf N-terminal cysteine-rich region
• Dickkopf-related protein 3, second cysteine-rich domain
• Dickkopf-related protein 3, N-terminal domain

KeywordsUniProt

• Coiled coil
• Developmental protein
• Disulfide bond
• Glycoprotein
• Secreted
• Signal
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of DKK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LRP5
• LRP6