DKK2

Protein identityUniProt · HPA

UniProt accession

Q9UBU2

Gene

DKK2

Ensembl

ENSG00000155011

Chromosome

4

Canonical length

259 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Golgi apparatus

Secretome location

Secreted in other tissues

OverviewNCBI Gene

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q9UBU2|DKK2
     1  MAALMRSKDS SCCLLLLAAV LMVESSQIGS SRAKLNSIKS SLGGETPGQA ANRSAGMYQG
    61  LAFGGSKKGK NLGQAYPCSS DKECEVGRYC HSPHQGSSAC MVCRRKKKRC HRDGMCCPST
   121  RCNNGICIPV TESILTPHIP ALDGTRHRDR NHGHYSNHDL GWQNLGRPHT KMSHIKGHEG
   181  DPCLRSSDCI EGFCCARHFW TKICKPVLHQ GEVCTKQRKK GSHGLEIFQR CDCAKGLSCK
   241  VWKDATYSSK ARLHVCQKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DKK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

14 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0.75

gnomAD missense Z

0.42

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of canonical Wnt signaling pathway
• positive regulation of canonical Wnt signaling pathway
• Wnt signaling pathway

Molecular functions

• co-receptor binding
• receptor antagonist activity

Cellular components

• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Dickkopf, N-terminal cysteine-rich
• Dickkopf related protein 1-4
• Dickkopf-related protein 1/2/4, C-terminal subdomain 2
• Dickkopf-related protein 1/2/4, C-terminal subdomain 1
• Dickkopf N-terminal cysteine-rich region
• Dickkopf-related protein 1/2/4, C-terminal subdomain 2
• Dickkopf-related protein 1/2/4, C-terminal subdomain 1
• Dickkopf-related protein 2, second cysteine-rich domain
• Dickkopf-related protein 2, first cysteine-rich domain

KeywordsUniProt

• Developmental protein
• Disulfide bond
• Glycoprotein
• Secreted
• Signal
• Wnt signaling pathway

InteractionsUniProt · HPA

Protein binding partners of DKK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LRP5
• LRP6