Seroatlas · Human Serome Atlas

DISP2

Protein dispatched homolog 2

Also known as: C15orf36, DISP2_HUMAN, DISPB, HsT16908, KIAA1742, LINC00594

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A7MBM2
Gene
DISP2
Ensembl
ENSG00000140323
Chromosome
15
Canonical length
1401 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene is one of two human homologs of a segment-polarity gene known as dispatched identified in Drosophila. The product of this gene may be required for normal Hedgehog (Hh) signaling during embryonic pattern formation. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

1401 residues, UniProt reviewed canonical sequence.

>A7MBM2|DISP2
     1  MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA SPERSCSLHS
    61  CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ EYQGGSSLPG LGDRAALCSH
   121  GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR QERAFQMPKS YSQLIAEWPV AVLMLCLAVI
   181  FLCTLAGLLG ARLPDFSKPL LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS
   241  SSSHNTLRPA PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW
   301  NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR SSCLDTTQAD
   361  AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT KCSQSSAIYQ LLHFLLDRDF
   421  LSPQTTDYQV PSLKYSLLFL PTPKGASLMD IYLDRLATPW GLADNYTSVT GMDLGLKQEL
   481  LRHFLVQDTV YPLLALVAIF FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF
   541  PFVNLAALLL LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT
   601  SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR GCARRARGRW
   661  EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI KFRYIWICWF AALAAGGAYI
   721  AGVSPRLRLP TLPPPGGQVF RPSHPFERFD AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP
   781  VDTGDPLDPR SNSSLVRDPA FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET
   841  LQRWMESPSC ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL
   901  AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR LELYSLQHSL
   961  STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV LLTVGLLVLL EWQLNTAEAL
  1021  FLSASVGLSV DFTVNYCISY HLCPHPDRLS RVAFSLRQTS CATAVGAAAL FAAGVLMLPA
  1081  TVLLYRKLGI ILMMVKCVSC GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG
  1141  GEKAGRPRPG SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD
  1201  GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ DSQGEEAEPL
  1261  PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL STSEPSARVP DSVGVSPDDL
  1321  DDTGQPVLER GQLNGKRDTL WLALRETVYD PSLPASHHSS LSWKGRGGPG DGSPVVLPNS
  1381  QPDLPDVWLR RPSTHTSGYS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DISP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 26 nTPM
  • cerebral cortex: 4.8 nTPM
  • hypothalamus: 4.3 nTPM
  • basal ganglia: 3 nTPM
  • hippocampal formation: 2.8 nTPM
  • amygdala: 2.6 nTPM

Single-cell type

  • brain excitatory neurons: 46 nCPM
  • paneth cells: 39 nCPM
  • goblet cells: 36 nCPM
  • other brain neurons: 34 nCPM
  • brain inhibitory neurons: 31 nCPM
  • colonocytes: 27 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • neutrophil: 0.4 nTPM
  • gdT-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • cerebellum: 50 nTPM
  • pons: 25 nTPM
  • cerebral cortex: 24 nTPM
  • basal ganglia: 24 nTPM
  • hypothalamus: 22 nTPM
  • medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.2
gnomAD missense Z
0.91
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DISP2 as an antibody target. Whether an autoantibody or antibody against DISP2 could matter depends on whether native DISP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DISP2 is annotated at the cell surface, where native DISP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DISP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DISP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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