Seroatlas · Human Serome Atlas

DIRC1

Disrupted in renal carcinoma protein 1

Also known as: DIRC1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969H9
Gene: DIRC1
Canonical length: 104 aa

OverviewNCBI Gene

No narrative summary is available for DIRC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

104 residues, UniProt reviewed canonical sequence.

>Q969H9|DIRC1
     1  MPEAHMQPAK LQTSLPTTDH GSKKPVSCYL PPLSNAHPMC IEVQNAQNCS SAAATLEPSI
    61  ISDTCFYKPI TKDQLSSRSE LNTVRLKCLN SLRGWKILNQ LSLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.07

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Disrupted in renal carcinoma protein 1
Disrupted in renal carcinoma protein 1

KeywordsUniProt

Chromosomal rearrangement

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIRC1 as an antibody target. Whether an autoantibody or antibody against DIRC1 could matter depends on whether native DIRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIRC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DIRC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...