Seroatlas · Human Serome Atlas

DIPK2B

Divergent protein kinase domain 2B

Also known as: CXorf36, DIA1R, DIK2B_HUMAN, FLJ14103

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7Y0
Gene: DIPK2B
Ensembl: ENSG00000147113
Chromosome: X
Canonical length: 433 aa
Protein class: Disease related genes, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q9H7Y0|DIPK2B
     1  MEPQLGPEAA ALRPGWLALL LWVSALSCSF SLPASSLSSL VPQVRTSYNF GRTFLGLDKC
    61  NACIGTSICK KFFKEEIRSD NWLASHLGLP PDSLLSYPAN YSDDSKIWRP VEIFRLVSKY
   121  QNEISDRRIC ASASAPKTCS IERVLRKTER FQKWLQAKRL TPDLVQGLAS PLLRCPSQRL
   181  LDRVVRRYAE VADAGSIFMD HFTDRDKLRL LYTLAVNSHP ILLQIFPGAE GWPLPKYLGS
   241  CGRFLVSTST RPLQEFYDAP PDQAADLAYQ LLGVLESLRS NDLNYFFYFT HIDAGMFGVF
   301  NNGHLFIRDA SAVGVIDKQE GSQEANRAGE NKDIFSCLVS GCQAQLPSCE SISEKQSLVL
   361  VCQKLLPRLL QGRFPSPVQD DIDSILVQCG DSIRPDPEVL GAASQLKDIL RPLRTCDSRF
   421  AYRYPDCKYN DKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIPK2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 39 nTPM
placenta: 38 nTPM
breast: 36 nTPM
heart muscle: 27 nTPM
endometrium: 22 nTPM
smooth muscle: 19 nTPM

Single-cell type

vascular endothelial cells: 280 nCPM
lymphatic endothelial cells: 248 nCPM
oligodendrocytes: 30 nCPM
thymic myoid cells: 9.5 nCPM
epicardial cells: 6.8 nCPM
respiratory ionocytes: 5.1 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 25 nTPM
basal ganglia: 25 nTPM
white matter: 25 nTPM
medulla oblongata: 24 nTPM
amygdala: 24 nTPM
midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIPK2B as an antibody target. Whether an autoantibody or antibody against DIPK2B could matter depends on whether native DIPK2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIPK2B is annotated as secreted, so native DIPK2B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DIPK2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...