Seroatlas · Human Serome Atlas

DIPK2A

Divergent protein kinase domain 2A

Also known as: C3orf58, DIA1, DIK2A_HUMAN, HASF, MGC33365

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDZ4
Gene: DIPK2A
Ensembl: ENSG00000181744
Chromosome: 3
Canonical length: 430 aa
Protein class: Disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Involved in several processes, including cardiac muscle cell proliferation; negative regulation of smooth muscle cell apoptotic process; and positive regulation of protein kinase C activity. Located in Golgi membrane and extracellular space. Part of COPI vesicle coat. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q8NDZ4|DIPK2A
     1  MWRLVPPKLG RLSRSLKLAA LGSLLVLMVL HSPSLLASWQ RNELTDRRFL QLNKCPACFG
    61  TSWCRRFLNG QVVFEAWGRL RLLDFLNVKN VYFAQYGEPR EGGRRRVVLK RLGSQRELAQ
   121  LDQSICKRAT GRPRCDLLQA MPRTEFARLN GDVRLLTPEA VEGWSDLVHC PSQRLLDRLV
   181  RRYAETKDSG SFLLRNLKDS ERMQLLLTLA FNPEPLVLQS FPSDEGWPFA KYLGACGRMV
   241  AVNYVGEELW SYFNAPWEKR VDLAWQLMEI AEQLTNNDFE FALYLLDVSF DNFAVGPRDG
   301  KVIIVDAENV LVADKRLIRQ NKPENWDVWY ESKFDDCDKE ACLSFSKEIL CARATVDHNY
   361  YAVCQNLLSR HATWRGTSGG LLHDPPSEIA KDGRLEALLD ECANPKKRYG RFQAAKELRE
   421  YLAQLSNNVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIPK2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

placenta: 36 nTPM
bone marrow: 31 nTPM
ovary: 24 nTPM
skin: 23 nTPM
liver: 18 nTPM
thymus: 16 nTPM

Single-cell type

bergmann glia: 263 nCPM
ependymal cells: 173 nCPM
pdcs: 172 nCPM
oligodendrocytes: 156 nCPM
platelets: 153 nCPM
medullary thymic epithelial cells: 132 nCPM

Immune cell

basophil: 25 nTPM
eosinophil: 20 nTPM
myeloid DC: 15 nTPM
classical monocyte: 12 nTPM
non-classical monocyte: 11 nTPM
NK-cell: 9.5 nTPM

Brain region

cerebellum: 54 nTPM
white matter: 52 nTPM
basal ganglia: 32 nTPM
cerebral cortex: 31 nTPM
medulla oblongata: 30 nTPM
pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIPK2A as an antibody target. Whether an autoantibody or antibody against DIPK2A could matter depends on whether native DIPK2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIPK2A is annotated as secreted, so native DIPK2A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DIPK2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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