Seroatlas · Human Serome Atlas

DIPK1C

Divergent protein kinase domain 1C

Also known as: C18orf51, DIK1C_HUMAN, FAM69C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0P6D2
Gene: DIPK1C
Ensembl: ENSG00000187773
Chromosome: 18
Canonical length: 419 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q0P6D2|DIPK1C
     1  MARAAGARGP AGWCRRRGRC GRGTLLAFAA WTAGWVLAAA LLLRAHPGVL SERCTDEKSR
    61  RILAALCQDY QGGTLAGDLC EDLCVAGELL FQRCLHYNRG KKVLQADWRG RPVVLKSKEE
   121  AFSSFPPLSL LEEEAGEGGQ DMPEAELLLM VAGEVKSALG LELSNSSLGP WWPGRRGPRW
   181  RGQLASLWAL LQQEEYVYFS LLQDLSPHVL PVLGSCGHFY AVEFLAAGSP HHRALFPLDR
   241  APGAPGGGQA KAISDIALSF LDMVNHFDSD FSHRLHLCDI KPENFAIRSD FTVVAIDVDM
   301  AFFEPKMREI LEQNCTGDED CNFFDCFSRC DLRVNKCGAQ RVNNNLQVIC DKIFRHWFSA
   361  PLKSSAVSFQ LQLQLQEAVQ ECADPGVPSG NTRRAASSVF WKLRQLLQAT LRELQEAEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIPK1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 36 nTPM
midbrain: 24 nTPM
amygdala: 24 nTPM
hippocampal formation: 20 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 16 nTPM

Single-cell type

müller glia: 219 nCPM
melanocytes: 53 nCPM
oligodendrocytes: 43 nCPM
astrocytes: 34 nCPM
oligodendrocyte progenitor cells: 30 nCPM
innate lymphoid cells: 25 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 39 nTPM
thalamus: 34 nTPM
basal ganglia: 33 nTPM
midbrain: 30 nTPM
cerebellum: 23 nTPM
hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIPK1C as an antibody target. Whether an autoantibody or antibody against DIPK1C could matter depends on whether native DIPK1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIPK1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DIPK1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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