Seroatlas · Human Serome Atlas

DIPK1B

Divergent protein kinase domain 1B

Also known as: C9orf136, DIK1B_HUMAN, FAM69B, MGC20262

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VUD6
Gene: DIPK1B
Ensembl: ENSG00000165716
Chromosome: 9
Canonical length: 431 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Vesicles

OverviewNCBI Gene

This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q5VUD6|DIPK1B
     1  MRRLRRLAHL VLFCPFSKRL QGRLPGLRVR CIFLAWLGVF AGSWLVYVHY SSYSERCRGH
    61  VCQVVICDQY RKGIISGSVC QDLCELHMVE WRTCLSVAPG QQVYSGLWRD KDVTIKCGIE
   121  ETLDSKARSD AAPRRELVLF DKPTRGTSIK EFREMTLSFL KANLGDLPSL PALVGQVLLM
   181  ADFNKDNRVS LAEAKSVWAL LQRNEFLLLL SLQEKEHASR LLGYCGDLYL TEGVPHGAWH
   241  AAALPPLLRP LLPPALQGAL QQWLGPAWPW RAKIAIGLLE FVEELFHGSY GTFYMCETTL
   301  ANVGYTATYD FKMADLQQVA PEATVRRFLQ GRRCEHSTDC TYGRDCRAPC DRLMRQCKGD
   361  LIQPNLAKVC ALLRGYLLPG APADLREELG TQLRTCTTLS GLASQVEAHH SLVLSHLKTL
   421  LWKKISNTKY S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIPK1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 42 nTPM
cerebral cortex: 31 nTPM
heart muscle: 28 nTPM
hypothalamus: 27 nTPM
amygdala: 24 nTPM
hippocampal formation: 24 nTPM

Single-cell type

platelets: 127 nCPM
megakaryocytes: 74 nCPM
hematopoietic stem cells: 58 nCPM
megakaryocyte-erythroid progenitors: 54 nCPM
vascular endothelial cells: 48 nCPM
megakaryocyte progenitors: 45 nCPM

Immune cell

naive B-cell: 2.8 nTPM
memory B-cell: 1 nTPM
plasmacytoid DC: 1 nTPM
total PBMC: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM

Brain region

cerebral cortex: 44 nTPM
cerebellum: 42 nTPM
thalamus: 39 nTPM
pons: 39 nTPM
amygdala: 34 nTPM
midbrain: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0.01
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIPK1B as an antibody target. Whether an autoantibody or antibody against DIPK1B could matter depends on whether native DIPK1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIPK1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DIPK1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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