Seroatlas · Human Serome Atlas

DIPK1A

Divergent protein kinase domain 1A

Also known as: DIK1A_HUMAN, FAM69A, FLJ23493

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T7M9
Gene: DIPK1A
Ensembl: ENSG00000154511
Chromosome: 1
Canonical length: 428 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q5T7M9|DIPK1A
     1  MARSLCPGAW LRKPYYLQAR FSYVRMKYLF FSWLVVFVGS WIIYVQYSTY TELCRGKDCK
    61  KIICDKYKTG VIDGPACNSL CVTETLYFGK CLSTKPNNQM YLGIWDNLPG VVKCQMEQAL
   121  HLDFGTELEP RKEIVLFDKP TRGTTVQKFK EMVYSLFKAK LGDQGNLSEL VNLILTVADG
   181  DKDGQVSLGE AKSAWALLQL NEFLLMVILQ DKEHTPKLMG FCGDLYVMES VEYTSLYGIS
   241  LPWVIELFIP SGFRRSMDQL FTPSWPRKAK IAIGLLEFVE DVFHGPYGNF LMCDTSAKNL
   301  GYNDKYDLKM VDMRKIVPET NLKELIKDRH CESDLDCVYG TDCRTSCDQS TMKCTSEVIQ
   361  PNLAKACQLL KDYLLRGAPS EIREELEKQL YSCIALKVTA NQMEMEHSLI LNNLKTLLWK
   421  KISYTNDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIPK1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

liver: 31 nTPM
cerebral cortex: 26 nTPM
smooth muscle: 24 nTPM
spinal cord: 24 nTPM
basal ganglia: 20 nTPM
hippocampal formation: 20 nTPM

Single-cell type

plasma cells: 288 nCPM
mesothelial cells: 270 nCPM
sertoli cells: 269 nCPM
epicardial cells: 264 nCPM
b-cells: 245 nCPM
oligodendrocytes: 238 nCPM

Immune cell

memory B-cell: 44 nTPM
naive B-cell: 27 nTPM
naive CD4 T-cell: 26 nTPM
NK-cell: 24 nTPM
memory CD4 T-cell: 22 nTPM
naive CD8 T-cell: 22 nTPM

Brain region

white matter: 54 nTPM
cerebral cortex: 39 nTPM
spinal cord: 39 nTPM
basal ganglia: 38 nTPM
cerebellum: 37 nTPM
medulla oblongata: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.58
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIPK1A as an antibody target. Whether an autoantibody or antibody against DIPK1A could matter depends on whether native DIPK1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIPK1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DIPK1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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