Seroatlas · Human Serome Atlas

DIAPH2-AS1

Early lymphoid activation gene protein

Also known as: EPAG_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14236
Gene: DIAPH2-AS1
Canonical length: 149 aa

OverviewNCBI Gene

No narrative summary is available for DIAPH2-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>Q14236|DIAPH2-AS1
     1  MNLYLHPKLW PQLAGTKTLH VADAQRVRKI TVHDGIWDAE LPRAKRNHSY HLRYHGSSYS
    61  RCFLERYRCK TIGVFRRSNQ PDCLETRSEK AKNRDGVVQE KSVRTLFSEC VNQCDIRRRP
   121  TRFLRMFYHQ KHFQLGLKGT ETEKNERRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DIAPH2-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6

OntologyGO

Biological processes

signal transduction

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DIAPH2-AS1 as an antibody target. Whether an autoantibody or antibody against DIAPH2-AS1 could matter depends on whether native DIAPH2-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DIAPH2-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DIAPH2-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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