Seroatlas · Human Serome Atlas

DHRS4-AS1

Putative uncharacterized protein DHRS4-AS1

Also known as: DHAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1J3
Gene: DHRS4-AS1
Canonical length: 65 aa

OverviewNCBI Gene

No narrative summary is available for DHRS4-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

65 residues, UniProt reviewed canonical sequence.

>Q9P1J3|DHRS4-AS1
     1  MSEQNICNQK DKSTLPFCQA HLCEETTNRL CVSNKAVYSL ECKWAESENR VSEGRWGRGC
    61  FIGVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHRS4-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHRS4-AS1 as an antibody target. Whether an autoantibody or antibody against DHRS4-AS1 could matter depends on whether native DHRS4-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHRS4-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHRS4-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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