Seroatlas · Human Serome Atlas

DHODH

Dihydroorotate dehydrogenase (quinone), mitochondrial

Also known as: PYRD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q02127
Gene
DHODH
Ensembl
ENSG00000102967
Chromosome
16
Canonical length
395 aa
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q02127|DHODH
     1  MAWRHLKKRA QDAVIILGGG GLLFASYLMA TGDERFYAEH LMPTLQGLLD PESAHRLAVR
    61  FTSLGLLPRA RFQDSDMLEV RVLGHKFRNP VGIAAGFDKH GEAVDGLYKM GFGFVEIGSV
   121  TPKPQEGNPR PRVFRLPEDQ AVINRYGFNS HGLSVVEHRL RARQQKQAKL TEDGLPLGVN
   181  LGKNKTSVDA AEDYAEGVRV LGPLADYLVV NVSSPNTAGL RSLQGKAELR RLLTKVLQER
   241  DGLRRVHRPA VLVKIAPDLT SQDKEDIASV VKELGIDGLI VTNTTVSRPA GLQGALRSET
   301  GGLSGKPLRD LSTQTIREMY ALTQGRVPII GVGGVSSGQD ALEKIRAGAS LVQLYTALTF
   361  WGPPVVGKVK RELEALLKEQ GFGGVTDAIG ADHRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DHODH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • liver: 59 nTPM
  • skeletal muscle: 9.4 nTPM
  • tongue: 7.5 nTPM
  • heart muscle: 7.4 nTPM
  • kidney: 7.4 nTPM
  • adipose tissue: 6.9 nTPM

Single-cell type

  • epicardial cells: 164 nCPM
  • hepatocytes: 148 nCPM
  • cardiomyocytes: 42 nCPM
  • oocytes: 32 nCPM
  • lymphatic endothelial cells: 27 nCPM
  • tuft cells: 23 nCPM

Immune cell

  • myeloid DC: 15 nTPM
  • plasmacytoid DC: 14 nTPM
  • MAIT T-cell: 13 nTPM
  • naive CD8 T-cell: 13 nTPM
  • memory B-cell: 12 nTPM
  • naive B-cell: 12 nTPM

Brain region

  • white matter: 14 nTPM
  • cerebral cortex: 13 nTPM
  • cerebellum: 12 nTPM
  • choroid plexus: 12 nTPM
  • basal ganglia: 12 nTPM
  • medulla oblongata: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DHODH.

Disease | AllUniProt

Conditions DHODH is implicated in, by any mechanism.

  • Postaxial acrofacial dysostosis (POADS) MIM:263750

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 217 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Miller syndrome
  • DHODH-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0
gnomAD missense Z
-0.34
DepMap mean gene effect
-0.36
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DHODH as an antibody target. Whether an autoantibody or antibody against DHODH could matter depends on whether native DHODH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DHODH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DHODH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DHODH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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