Seroatlas · Human Serome Atlas

DGLUCY

D-glutamate cyclase, mitochondrial

Also known as: C14orf159, FLJ39975, GLUCM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3D6
Gene: DGLUCY
Ensembl: ENSG00000133943
Chromosome: 14
Canonical length: 616 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable D-glutamate cyclase activity. Predicted to be involved in glutamate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

616 residues, UniProt reviewed canonical sequence.

>Q7Z3D6|DGLUCY
     1  MPFTLHLRSR LPSAIRSLIL QKKPNIRNTS SMAGELRPAS LVVLPRSLAP AFERFCQVNT
    61  GPLPLLGQSE PEKWMLPPQG AISETRMGHP QFWKYEFGAC TGSLASLEQY SEQLKDMVAF
   121  FLGCSFSLEE ALEKAGLPRR DPAGHSQTTV PCVTHAGFCC PLVVTMRPIP KDKLEGLVRA
   181  CCSLGGEQGQ PVHMGDPELL GIKELSKPAY GDAMVCPPGE VPVFWPSPLT SLGAVSSCET
   241  PLAFASIPGC TVMTDLKDAK APPGCLTPER IPEVHHISQD PLHYSIASVS ASQKIRELES
   301  MIGIDPGNRG IGHLLCKDEL LKASLSLSHA RSVLITTGFP THFNHEPPEE TDGPPGAVAL
   361  VAFLQALEKE VAIIVDQRAW NLHQKIVEDA VEQGVLKTQI PILTYQGGSV EAAQAFLCKN
   421  GDPQTPRFDH LVAIERAGRA ADGNYYNARK MNIKHLVDPI DDLFLAAKKI PGISSTGVGD
   481  GGNELGMGKV KEAVRRHIRH GDVIACDVEA DFAVIAGVSN WGGYALACAL YILYSCAVHS
   541  QYLRKAVGPS RAPGDQAWTQ ALPSVIKEEK MLGILVQHKV RSGVSGIVGM EVDGLPFHNT
   601  HAEMIQKLVD VTTAQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DGLUCY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 153 nTPM

Expression across tissuesHPA

Tissue

tongue: 153 nTPM
skeletal muscle: 134 nTPM
heart muscle: 114 nTPM
choroid plexus: 65 nTPM
parathyroid gland: 45 nTPM
cerebral cortex: 41 nTPM

Single-cell type

cardiomyocytes: 462 nCPM
choroid plexus epithelial cells: 397 nCPM
myonuclei: 354 nCPM
ependymal cells: 228 nCPM
neutrophils: 226 nCPM
corticotrophs: 218 nCPM

Immune cell

neutrophil: 202 nTPM
myeloid DC: 73 nTPM
intermediate monocyte: 69 nTPM
basophil: 68 nTPM
non-classical monocyte: 61 nTPM
classical monocyte: 49 nTPM

Brain region

choroid plexus: 153 nTPM
cerebellum: 104 nTPM
midbrain: 102 nTPM
thalamus: 90 nTPM
medulla oblongata: 89 nTPM
basal ganglia: 88 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

glutamate metabolic process

Molecular functions

D-glutamate cyclase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

D-glutamate cyclase-like domain
D-glutamate cyclase, mitochondrial
D-glutamate cyclase-like, C-terminal
Putative hydro-lyase
D-glutamate cyclase
D-glutamate cyclase-like, C-terminal

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DGLUCY as an antibody target. Whether an autoantibody or antibody against DGLUCY could matter depends on whether native DGLUCY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DGLUCY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DGLUCY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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