Seroatlas · Human Serome Atlas

DGAT1

Diacylglycerol O-acyltransferase 1

Also known as: ARGP1, DGAT, DGAT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75907
Gene
DGAT1
Ensembl
ENSG00000185000
Chromosome
8
Canonical length
488 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoli,Nucleoli rim,Endoplasmic reticulum
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>O75907|DGAT1
     1  MGDRGSSRRR RTGSRPSSHG GGGPAAAEEE VRDAAAGPDV GAAGDAPAPA PNKDGDAGVG
    61  SGHWELRCHR LQDSLFSSDS GFSNYRGILN WCVVMLILSN ARLFLENLIK YGILVDPIQV
   121  VSLFLKDPYS WPAPCLVIAA NVFAVAAFQV EKRLAVGALT EQAGLLLHVA NLATILCFPA
   181  AVVLLVESIT PVGSLLALMA HTILFLKLFS YRDVNSWCRR ARAKAASAGK KASSAAAPHT
   241  VSYPDNLTYR DLYYFLFAPT LCYELNFPRS PRIRKRFLLR RILEMLFFTQ LQVGLIQQWM
   301  VPTIQNSMKP FKDMDYSRII ERLLKLAVPN HLIWLIFFYW LFHSCLNAVA ELMQFGDREF
   361  YRDWWNSESV TYFWQNWNIP VHKWCIRHFY KPMLRRGSSK WMARTGVFLA SAFFHEYLVS
   421  VPLRMFRLWA FTGMMAQIPL AWFVGRFFQG NYGNAAVWLS LIIGQPIAVL MYVHDYYVLN
   481  YEAPAAEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DGAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 42 nTPM
  • duodenum: 35 nTPM
  • adrenal gland: 25 nTPM
  • cerebellum: 24 nTPM
  • liver: 18 nTPM
  • testis: 18 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 24 nCPM
  • enterocytes: 21 nCPM
  • adrenal cortex cells: 20 nCPM
  • astrocytes: 19 nCPM
  • brain excitatory neurons: 15 nCPM
  • brain inhibitory neurons: 15 nCPM

Immune cell

  • eosinophil: 0.7 nTPM
  • myeloid DC: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • MAIT T-cell: 0.4 nTPM
  • non-classical monocyte: 0.4 nTPM

Brain region

  • cerebellum: 7.2 nTPM
  • cerebral cortex: 5.7 nTPM
  • midbrain: 5.7 nTPM
  • hippocampal formation: 5.6 nTPM
  • amygdala: 5.4 nTPM
  • basal ganglia: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DGAT1.

Disease | AllUniProt

Conditions DGAT1 is implicated in, by any mechanism.

  • Diarrhea 7, protein-losing enteropathy type (DIAR7) MIM:615863

Disease | GeneticClinVar

75 pathogenic / likely-pathogenic of 783 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
1.04
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DGAT1 as an antibody target. Whether an autoantibody or antibody against DGAT1 could matter depends on whether native DGAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DGAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DGAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DGAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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