Seroatlas · Human Serome Atlas

DEXI

Dexamethasone-induced protein

Also known as: DEXI_HUMAN, MYLE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95424
Gene
DEXI
Ensembl
ENSG00000182108
Chromosome
16
Canonical length
95 aa
Protein class
Predicted membrane proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

No narrative summary is available for DEXI in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>O95424|DEXI
     1  MLGARVAAHL DALGPLVPYV PPPLLPSMFY VGLFFVNVLI LYYAFLMEYI VLNVGLVFLP
    61  EDMDQALVDL GVLSDPGSGL YDADSELDVF DAYLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEXI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
121 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 121 nTPM
  • heart muscle: 96 nTPM
  • liver: 89 nTPM
  • adrenal gland: 81 nTPM
  • blood vessel: 60 nTPM
  • basal ganglia: 58 nTPM

Single-cell type

  • hepatocytes: 127 nCPM
  • cdc: 119 nCPM
  • hepatic stellate cells: 78 nCPM
  • hofbauer cells: 73 nCPM
  • epididymal principal cells: 71 nCPM
  • peritubular myoid cells: 70 nCPM

Immune cell

  • eosinophil: 7.2 nTPM
  • memory CD8 T-cell: 5.4 nTPM
  • gdT-cell: 4.8 nTPM
  • naive CD4 T-cell: 4.7 nTPM
  • naive CD8 T-cell: 4.7 nTPM
  • MAIT T-cell: 4.2 nTPM

Brain region

  • thalamus: 103 nTPM
  • pons: 90 nTPM
  • cerebellum: 85 nTPM
  • cerebral cortex: 85 nTPM
  • medulla oblongata: 84 nTPM
  • midbrain: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.67
gnomAD pLI
0.41
gnomAD missense Z
-0.11

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Dexamethasone-induced protein
  • Dexamethasone-induced

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEXI as an antibody target. Whether an autoantibody or antibody against DEXI could matter depends on whether native DEXI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEXI is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DEXI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DEXI. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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