Seroatlas · Human Serome Atlas

DERPC

Decreased expression in renal and prostate cancer protein

Also known as: DERPC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG12
Gene: DERPC
Ensembl: ENSG00000286140
Chromosome: 16
Canonical length: 524 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>P0CG12|DERPC
     1  MKEPRIFPRE RPTPWTRAPL PPRGRLDGSL GPQGGPVLNT GHPLGVNSDP FLMAAGSLGG
    61  NLTPFPRNPS PFPASSGSLA SNPAPFPAGA RDPSMASFPR GMNPTGTGAV SFPRPGGLLG
   121  PGPGPGPTLN PRTGALPGPG PLSNPRLGGL PGPGPMSNPR AGGLLGAGPD PRGGGPMGPG
   181  SGPNLRAGVL LTSGNGPPNP RPVGLGPGPN PNLRSGFLGT NPAPRSGVFP GPGLGPNPRP
   241  SGLGPGPNLD ARAGGLLGTG SGLNLRMAGP QGLDLAPILR AAGLLGANSA SFSQASGNMG
   301  TSPSSMARVP GPMGPNSGPS SRGIGLPGPN PSPMSRAPGP IGPNSAHFSR PVGPMGVNAN
   361  PFPRGAGSSA FSQSSGTLAS NPATFQRSAG LQGSNPTIFP RASGPLGPNP ANFPRATGLQ
   421  GPSPTTFPRS TGPLGPGQVT FPRPAAGHLG PSPAGPVGIN PAPFTRPTGT LGLNPASFPR
   481  MNGPAGKSFV PFPRVGSLPG TNPAAFPRPG GPMAAMYPNG MLPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DERPC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.76
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

epididymis: 25 nTPM
placenta: 18 nTPM
tonsil: 18 nTPM
lymph node: 17 nTPM
thymus: 17 nTPM
choroid plexus: 16 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

intermediate monocyte: 14 nTPM
non-classical monocyte: 14 nTPM
myeloid DC: 13 nTPM
total PBMC: 13 nTPM
classical monocyte: 13 nTPM
plasmacytoid DC: 13 nTPM

Brain region

choroid plexus: 16 nTPM
medulla oblongata: 15 nTPM
thalamus: 15 nTPM
spinal cord: 15 nTPM
amygdala: 15 nTPM
white matter: 14 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DERPC as an antibody target. Whether an autoantibody or antibody against DERPC could matter depends on whether native DERPC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DERPC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DERPC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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