DEPP1
Protein DEPP1
Also known as: C10orf10, DEPP, DEPP1_HUMAN, FIG, Fseg
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NTK1
- Gene
- DEPP1
- Ensembl
- ENSG00000165507
- Chromosome
- 10
- Canonical length
- 212 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Mitochondria
OverviewNCBI Gene
The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
212 residues, UniProt reviewed canonical sequence.
>Q9NTK1|DEPP1
1 MRSRLLLSVA HLPTIRETTE EMLLGGPGQE PPPSPSLDDY VRSISRLAQP TSVLDKATAQ
61 GQPRPPHRPA QACRKGRPAV SLRDITARFS GQQPTLPMAD TVDPLDWLFG ESQEKQPSQR
121 DLPRRTGPSA GLWGPHRQMD SSKPMGAPRG RLCEARMPGH SLARPPQDGQ QSSDLRSWTF
181 GQSAQAMASR HRPRPSSVLR TLYSHLPVIH ELLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.7
- Highest tissue expression
- 858 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 858 nTPM
- breast: 688 nTPM
- blood vessel: 660 nTPM
- lung: 488 nTPM
- pancreas: 337 nTPM
- ovary: 278 nTPM
Single-cell type
- decidual stromal cells: 533 nCPM
- syncytiotrophoblasts: 403 nCPM
- thymic myoid cells: 313 nCPM
- fibroblasts: 303 nCPM
- vascular endothelial cells: 300 nCPM
- pancreatic islet cells: 283 nCPM
Immune cell
- plasmacytoid DC: 1 nTPM
- total PBMC: 0.4 nTPM
- eosinophil: 0.3 nTPM
- naive CD4 T-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
Brain region
- medulla oblongata: 298 nTPM
- spinal cord: 144 nTPM
- pons: 124 nTPM
- white matter: 116 nTPM
- thalamus: 112 nTPM
- hypothalamus: 80 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.83
- gnomAD pLI
- 0.34
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Decidual protein, progesterone induced
- Decidual protein induced by progesterone family
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEPP1 as an antibody target. Whether an autoantibody or antibody against DEPP1 could matter depends on whether native DEPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DEPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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