Seroatlas · Human Serome Atlas

DENND2C

DENN domain-containing protein 2C

Also known as: DEN2C_HUMAN, dJ1156J9.1, DKFZp686G0351, DKFZp779P1149, FLJ37099, RP5-1156J9.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68D51
Gene: DENND2C
Ensembl: ENSG00000175984
Chromosome: 1
Canonical length: 928 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

928 residues, UniProt reviewed canonical sequence.

>Q68D51|DENND2C
     1  MDVGFSRTTV QTLSRSHCKN IKQKISQWEG RANGISNPEK WCPKDFGVRY NCHQEIRLKK
    61  NPIAERKSKN LDVTSRENVG LDINENTKSH DQSENENKKH EYDDTHFFKN ESESNWVCSR
   121  VKEIESCKED VLDPETSLPP GNFYTSQILW KKIEALPPDK LLNLALEHCD SSEKELNFRV
   181  LDSSYGITKS LENIYSEPEG QECGPSINPL PKPRRTFRYL SESGVTPYKE RNCDKKYCEN
   241  NSCAQSSLAS SQEPEPKKYG GKIRGRSKRK SFEFEDIQHF RNRNSQTIRE ELGRNSGSAL
   301  YYTQSEDNIY EDIIYPTKEN PYEDIPVQPL PMWRSPSAWK LPPAKSAFKA PKLPPKPQFL
   361  HRKTMEVKNS QAYLRSKLTK DTTLPVTLTE WKLFRAGEVA NTKRKNLPRL VLKIDDIFES
   421  KRGKKKVKLH SYTGKELPPT KGETSGNESD AEYLPKNRHK RLAQLQPSSK RNPHYQTLER
   481  DLIELQEQQL FELFVVVSLQ KKPSGISYIP QVIQQFPGKD DHGYKQSKDM EERLKVIPKF
   541  CFPDSKDWMP TSELKSETFS FVLTGEDGSR WFGYCKKLLP VGKGKRLPEV YCMVSRLGCF
   601  NLFSKILDEV EKRREMSPAL VYPFMRSVME APFPAPGRTI TVKSYLPGAG DESIELCRPL
   661  DSRLEHVDFK CLFKCLSVCH LIRVCASLLL ERRVIFVANS LSTLSKCGHA VVATLYPFTW
   721  QHTYIPVLPA SMIDIVCSPT PFLIGILSCS LPQLQDLPIE EVLIVDLCAD KFLQEVSDED
   781  EILPPKLQAA LMQILEERNE ILTQEQNFSQ DVTLNSLVSE AFVRFFVELV GHYSLNMTVT
   841  ERGERVFQRE PFRKSHTSRS VRHFLDLFME TQMFAGFIQD RELRKSGVKG LFEIRAIQYL
   901  ETIPESEPSG MNRILRSLGS KMKFLQKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DENND2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 39 nTPM
esophagus: 17 nTPM
skin: 12 nTPM
vagina: 6.8 nTPM
cervix: 5.1 nTPM
testis: 5.1 nTPM

Single-cell type

esophageal apical cells: 1,928 nCPM
myonuclei: 1,581 nCPM
ocular epithelial cells: 1,319 nCPM
urothelial cells: 1,087 nCPM
esophageal suprabasal cells: 997 nCPM
suprabasal keratinocytes: 921 nCPM

Immune cell

basophil: 3 nTPM
eosinophil: 0.9 nTPM
MAIT T-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

choroid plexus: 5.8 nTPM
hippocampal formation: 3.4 nTPM
cerebellum: 3.1 nTPM
cerebral cortex: 3 nTPM
basal ganglia: 2.9 nTPM
amygdala: 2.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DENND2C.

Disease | ImmuneIEDB

Conditions an epitope on DENND2C was assayed in.

food allergy B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DENND2C as an antibody target. Whether an autoantibody or antibody against DENND2C could matter depends on whether native DENND2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DENND2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DENND2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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