Seroatlas · Human Serome Atlas

DENND2A

DENN domain-containing protein 2A

Also known as: DEN2A_HUMAN, FAM31D, KIAA1277

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULE3
Gene: DENND2A
Ensembl: ENSG00000146966
Chromosome: 7
Canonical length: 1009 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Involved in retrograde transport, endosome to Golgi. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1009 residues, UniProt reviewed canonical sequence.

>Q9ULE3|DENND2A
     1  MDMFSLDMII SDPAAEASRA GKKQLRGVQN PCPSARARPR HKSLNIKDKI SEWEGKKEVP
    61  TPAPSRRADG QEDYLPSSTV ERRSSDGVRT QVTEAKNGMR PGTESTEKER NKGAVNVGGQ
   121  DPEPGQDLSQ PEREVDPSWG RGREPRLGKL RFQNDPLSVL KQVKKLEQAL KDGSAGLDPQ
   181  LPGTCYSPHC PPDKAEAGST LPENLGGGSG SEVSQRVHPS DLEGREPTPE LVEDRKGSCR
   241  RPWDRSLENV YRGSEGSPTK PFINPLPKPR RTFKHAGEGD KDGKPGIGFR KEKRNLPPLP
   301  SLPPPPLPSS PPPSSVNRRL WTGRQKSSAD HRKSYEFEDL LQSSSESSRV DWYAQTKLGL
   361  TRTLSEENVY EDILDPPMKE NPYEDIELHG RCLGKKCVLN FPASPTSSIP DTLTKQSLSK
   421  PAFFRQNSER RNFKLLDTRK LSRDGTGSPS KISPPSTPSS PDDIFFNLGD PQNGRKKRKI
   481  PKLVLRINAI YEVRRGKKRV KRLSQSMESN SGKVTDENSE SDSDTEEKLK AHSQRLVNVK
   541  SRLKQAPRYP SLARELIEYQ ERQLFEYFVV VSLHKKQAGA AYVPELTQQF PLKLERSFKF
   601  MREAEDQLKA IPQFCFPDAK DWVPVQQFTS ETFSFVLTGE DGSRRFGYCR RLLPGGKGKR
   661  LPEVYCIVSR LGCFSLFSRI LDEVEKRRGI SPALVQPLMR SVMEAPFPAL GKTILVKNFL
   721  PGSGTEVIEL CRPLDSRLEH VDFESLFSSL SVRHLVCVFA SLLLERRVIF IADKLSILSK
   781  CCHAMVALIY PFAWQHTYIP VLPPAMVDIV CSPTPFLIGL LSSSLPLLRE LPLEEVLVVD
   841  LVNSRFLRQM DDEDSILPRK LQVALEHILE QRNELACEQD EGPLDGRHGP ESSPLNEVVS
   901  EAFVRFFVEI VGHYSLFLTS GEREERTLQR EAFRKAVSSK SLRHFLEVFM ETQMFRGFIQ
   961  ERELRRQDAK GLFEVRAQEY LETLPSGEHS GVNKFLKGLG NKMKFLHKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DENND2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 33 nTPM
fallopian tube: 32 nTPM
midbrain: 29 nTPM
endometrium: 26 nTPM
basal ganglia: 26 nTPM
pituitary gland: 26 nTPM

Single-cell type

thyrotrophs: 702 nCPM
somatotrophs: 633 nCPM
retinal horizontal cells: 575 nCPM
choroid plexus epithelial cells: 568 nCPM
lactotrophs: 374 nCPM
fibro-adipogenic progenitors: 360 nCPM

Immune cell

neutrophil: 1.1 nTPM
basophil: 1 nTPM
NK-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
memory B-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM

Brain region

choroid plexus: 90 nTPM
medulla oblongata: 85 nTPM
midbrain: 77 nTPM
spinal cord: 66 nTPM
pons: 63 nTPM
basal ganglia: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.07
gnomAD missense Z: 1.17
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DENND2A as an antibody target. Whether an autoantibody or antibody against DENND2A could matter depends on whether native DENND2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DENND2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DENND2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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