Seroatlas · Human Serome Atlas

DENND11

DENN domain-containing protein 11

Also known as: DEN11_HUMAN, KIAA1147, LCHN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D1U4
Gene: DENND11
Ensembl: ENSG00000257093
Chromosome: 7
Canonical length: 455 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>A4D1U4|DENND11
     1  MVEQGDAAPL LRWAEGPAVS LPQAPQPQAG GWGRGGGGGA RPAAEPPRRR EPEEPAAPEV
    61  LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD IDLEGVEFKS MASGSHKIQS
   121  DFIYFRKGPF FGLACFANMP VESELERGAR MKSVGILSPS YTLLYRYMHF LENQVRHQLE
   181  MPGHYSHLAA FYEDKKGVLH AGPGRGSSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK
   241  FFGEQILILW KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY
   301  VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL LKINSADREK
   361  YRRLNEQRQM LLYSQEVEED YNPCEEDLFV LFFLEQNNRI FQTLLEVSAS QDKTLTAEHA
   421  RGMGLDPQGD RSFLLDLLEA YGIDVMLVID NPCCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DENND11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 23 nTPM
midbrain: 20 nTPM
salivary gland: 20 nTPM
hippocampal formation: 19 nTPM
amygdala: 19 nTPM
cerebellum: 17 nTPM

Single-cell type

microglia: 185 nCPM
oligodendrocytes: 101 nCPM
astrocytes: 49 nCPM
brain inhibitory neurons: 48 nCPM
bergmann glia: 47 nCPM
brain excitatory neurons: 47 nCPM

Immune cell

basophil: 1.7 nTPM
memory B-cell: 0.2 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 27 nTPM
white matter: 27 nTPM
medulla oblongata: 24 nTPM
pons: 23 nTPM
basal ganglia: 22 nTPM
hippocampal formation: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Tripartite DENN domain
DENND11/AVL9 guanine nucleotide exchange factors
Protein LCHN/Anr2
DENN domain-containing protein 11

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DENND11 as an antibody target. Whether an autoantibody or antibody against DENND11 could matter depends on whether native DENND11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DENND11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DENND11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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