Seroatlas · Human Serome Atlas

DENND10P1

Putative DENN domain-containing protein 10 B

Also known as: DE10B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NSW5
Gene: DENND10P1
Canonical length: 357 aa

OverviewNCBI Gene

No narrative summary is available for DENND10P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q6NSW5|DENND10P1
     1  MAAAELADTQ LMLGVGLIEK DTNGEVLWVW CYPSTTATLR NLLLRKCCLT DENKLLHPFV
    61  FGQYRRTWFY ITIIEVPDSS ILKKVTHFSI VLTAKDFNPE KYAAFTRILC RMYLKHGSPV
   121  KMMESYIAVL TKGICQSEEN GSFLSKDFDA RKAYPAGSIK DIVSQFGMET VILHTALMLK
   181  KRIVVYHPKI EAVQEFTRTL PALVWHRQDW TILHSYVHLN ADELEALQMC TGYVAGFVDL
   241  EVSNRPDLYD VFVNLAESEI TIAPLAKEAM AMGKLHKEMG QLIVQSAEDP EKSESQVIQD
   301  IALKTREIFT NLAPFSEVSA DGEKRVLNLE ALKQKRFPPA TENFLYHLAA AEQMLKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DENND10P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

late endosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DENND10P1 as an antibody target. Whether an autoantibody or antibody against DENND10P1 could matter depends on whether native DENND10P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DENND10P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DENND10P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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