Seroatlas · Human Serome Atlas

DELEC1

Deleted in esophageal cancer 1

Also known as: DEC1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2X7
Gene: DELEC1
Canonical length: 70 aa

OverviewNCBI Gene

No narrative summary is available for DELEC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

70 residues, UniProt reviewed canonical sequence.

>Q9P2X7|DELEC1
     1  MTMNVLEAGK WKSIVPAPGE GLLAVLHMMV FTDALHRERS VKWQAGVCYN GGKDFAVSLA
    61  RPKAAEGIAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DELEC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of cell population proliferation

Protein domainsUniProt · Pfam · InterPro

Deleted in esophageal cancer 1
Deleted in esophageal cancer 1 family

KeywordsUniProt

Tumor suppressor

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DELEC1 as an antibody target. Whether an autoantibody or antibody against DELEC1 could matter depends on whether native DELEC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DELEC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DELEC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...