DEFB4A
Defensin beta 4A
Also known as: DEFB-2, DEFB102, DEFB2, DEFB4, DEFB4B, DEFB4P, DFB4A_HUMAN, HBD-2, SAP1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O15263
- Gene
- DEFB4A
- Ensembl
- ENSG00000171711
- Chromosome
- 8
- Canonical length
- 64 aa
- Protein class
- Predicted secreted proteins, Transporters
- Secretome location
- Secreted in other tissues
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
Canonical amino-acid sequenceUniProt
64 residues, UniProt reviewed canonical sequence.
>O15263|DEFB4A
1 MRVLYLLFSF LFIFLMPLPG VFGGIGDPVT CLKSGAICHP VFCPRRYKQI GTCGLPGTKC
61 CKKPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEFB4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 151 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 151 nTPM
- cervix: 72 nTPM
- salivary gland: 30 nTPM
- vagina: 15 nTPM
- lung: 10 nTPM
- stomach: 7.8 nTPM
Single-cell type
- esophageal apical cells: 147 nCPM
- foveolar cells: 68 nCPM
- endometrial secretory cells: 26 nCPM
- suprabasal keratinocytes: 20 nCPM
- esophageal suprabasal cells: 16 nCPM
- ocular epithelial cells: 15 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.97
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.63
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antifungal innate immune response
- antimicrobial humoral immune response mediated by antimicrobial peptide
- cell chemotaxis
- chemotaxis
- defense response to bacterium
- defense response to fungus
- defense response to Gram-negative bacterium
- defense response to Gram-positive bacterium
- G protein-coupled receptor signaling pathway
- immune response
- killing of cells of another organism
Molecular functions
- CCR6 chemokine receptor binding
- chemoattractant activity
- phosphatidylinositol-4,5-bisphosphate binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEFB4A as an antibody target. Whether an autoantibody or antibody against DEFB4A could matter depends on whether native DEFB4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEFB4A is annotated as secreted, so native DEFB4A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label DEFB4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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