DEFB136
Defensin beta 136
Also known as: DB136_HUMAN, DEFB137
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q30KP8
- Gene
- DEFB136
- Ensembl
- ENSG00000205884
- Chromosome
- 8
- Canonical length
- 78 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
Canonical amino-acid sequenceUniProt
78 residues, UniProt reviewed canonical sequence.
>Q30KP8|DEFB136
1 MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW IAFCHNILSC
61 CKNMTRFQPP QAKDPWVHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEFB136 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 1.1 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 1.1 nTPM
- prostate: 0.1 nTPM
- retina: 0.1 nTPM
- seminal vesicle: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
Single-cell type
- late spermatids: 0.6 nCPM
- epididymal principal cells: 0.2 nCPM
- corticotrophs: 0.1 nCPM
- prostatic club cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 1.6 nTPM
- white matter: 1.4 nTPM
- cerebellum: 1.2 nTPM
- basal ganglia: 1 nTPM
- amygdala: 0.9 nTPM
- hypothalamus: 0.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0.09
- gnomAD missense Z
- -0.38
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- antibacterial innate immune response
- antifungal innate immune response
- defense response to Gram-negative bacterium
- defense response to Gram-positive bacterium
- killing of cells of another organism
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Beta-defensin 136/42
- Beta defensin 136
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEFB136 as an antibody target. Whether an autoantibody or antibody against DEFB136 could matter depends on whether native DEFB136 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEFB136 is annotated as secreted, so native DEFB136 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label DEFB136 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...