DEFB135
Beta-defensin 135
Also known as: DB135_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q30KP9
- Gene
- DEFB135
- Ensembl
- ENSG00000205883
- Chromosome
- 8
- Canonical length
- 77 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014]
Canonical amino-acid sequenceUniProt
77 residues, UniProt reviewed canonical sequence.
>Q30KP9|DEFB135
1 MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK NEQYRILCDT
61 IHLCCVNPKY LPILTGKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEFB135 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 53 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 53 nTPM
- retina: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- epididymal principal cells: 22 nCPM
- brain excitatory neurons: 0.2 nCPM
- brain inhibitory neurons: 0.2 nCPM
- other brain neurons: 0.2 nCPM
- papillary tip epithelial cells: 0.2 nCPM
- astrocytes: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 2.6 nTPM
- choroid plexus: 2.4 nTPM
- cerebellum: 2.2 nTPM
- white matter: 1.9 nTPM
- hypothalamus: 1.7 nTPM
- basal ganglia: 1.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.98
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.26
- DepMap mean gene effect
- -0.12
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEFB135 as an antibody target. Whether an autoantibody or antibody against DEFB135 could matter depends on whether native DEFB135 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEFB135 is annotated as secreted, so native DEFB135 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label DEFB135 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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