Seroatlas · Human Serome Atlas

DEFB132

Beta-defensin 132

Also known as: DB132_HUMAN, DEFB32, RP5-1103G7.6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7B7
Gene: DEFB132
Ensembl: ENSG00000186458
Chromosome: 20
Canonical length: 95 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. This protein binds spermatozoa and has antimicrobial activity against E. coli. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>Q7Z7B7|DEFB132
     1  MKFLLLVLAA LGFLTQVIPA SAGGSKCVSN TPGYCRTCCH WGETALFMCN ASRKCCISYS
    61  FLPKPDLPQL IGNHWQSRRR NTQRKDKKQQ TTVTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEFB132 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 256 nTPM

Expression across tissuesHPA

Tissue

epididymis: 256 nTPM
adipose tissue: 24 nTPM
seminal vesicle: 19 nTPM
prostate: 3.7 nTPM
breast: 1.4 nTPM
liver: 0.7 nTPM

Single-cell type

epididymal principal cells: 666 nCPM
epididymal clear cells: 10 nCPM
prostatic glandular cells: 5.2 nCPM
epididymal basal cells: 5.1 nCPM
mast cells: 3.1 nCPM
cholangiocytes: 2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEFB132 as an antibody target. Whether an autoantibody or antibody against DEFB132 could matter depends on whether native DEFB132 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEFB132 is annotated as secreted, so native DEFB132 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DEFB132 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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