Seroatlas · Human Serome Atlas

DEFB131B

Beta-defensin 131B

Also known as: D131B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A096LNP1
Gene
DEFB131B
Ensembl
ENSG00000225805
Chromosome
11
Canonical length
70 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be involved in defense response to bacterium and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

70 residues, UniProt reviewed canonical sequence.

>A0A096LNP1|DEFB131B
     1  MRVLFFVFGV LSLMSTVPPT RSFTSNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK
    61  IIQIDGQKKW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEFB131B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 57 nTPM
  • gallbladder: 0.8 nTPM
  • thyroid gland: 0.7 nTPM
  • retina: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • duodenum: 0.3 nTPM

Single-cell type

  • epididymal principal cells: 40 nCPM
  • epicardial cells: 11 nCPM
  • retinal ganglion cells: 7.7 nCPM
  • adipocytes: 6.3 nCPM
  • cardiomyocytes: 4.5 nCPM
  • fibro-adipogenic progenitors: 3.9 nCPM

Immune cell

  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 3.5 nTPM
  • cerebral cortex: 3.2 nTPM
  • amygdala: 2.3 nTPM
  • hypothalamus: 2.3 nTPM
  • thalamus: 2.3 nTPM
  • white matter: 2.3 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEFB131B as an antibody target. Whether an autoantibody or antibody against DEFB131B could matter depends on whether native DEFB131B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEFB131B is annotated as secreted, so native DEFB131B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DEFB131B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DEFB131B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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