DEFB131A
Beta-defensin 131A
Also known as: D131A_HUMAN, DEFB-31, DEFB131
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P59861
- Gene
- DEFB131A
- Ensembl
- ENSG00000186146
- Chromosome
- 4
- Canonical length
- 70 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 4p16. [provided by RefSeq, Nov 2014]
Canonical amino-acid sequenceUniProt
70 residues, UniProt reviewed canonical sequence.
>P59861|DEFB131A
1 MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK
61 IIEIDGQKKWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEFB131A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 126 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 126 nTPM
- duodenum: 9.8 nTPM
- seminal vesicle: 7.1 nTPM
- small intestine: 3 nTPM
- thyroid gland: 2 nTPM
- skin: 1.1 nTPM
Single-cell type
- epididymal principal cells: 385 nCPM
- enterocytes: 12 nCPM
- epididymal basal cells: 2.6 nCPM
- epididymal efferent duct ciliated cells: 2.1 nCPM
- epididymal clear cells: 2 nCPM
- renal collecting duct principal cells: 1.9 nCPM
Immune cell
- NK-cell: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- pons: 2.5 nTPM
- medulla oblongata: 1.4 nTPM
- white matter: 1.4 nTPM
- cerebral cortex: 1.2 nTPM
- midbrain: 1.2 nTPM
- thalamus: 1.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0.01
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEFB131A as an antibody target. Whether an autoantibody or antibody against DEFB131A could matter depends on whether native DEFB131A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEFB131A is annotated as secreted, so native DEFB131A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label DEFB131A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...