DEFB128
Beta-defensin 128
Also known as: DB128_HUMAN, DEFB-28
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7Z7B8
- Gene
- DEFB128
- Ensembl
- ENSG00000185982
- Chromosome
- 20
- Canonical length
- 93 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Canonical amino-acid sequenceUniProt
93 residues, UniProt reviewed canonical sequence.
>Q7Z7B8|DEFB128
1 MKLFLVLIIL LFEVLTDGAR LKKCFNKVTG YCRKKCKVGE RYEIGCLSGK LCCANDEEEK
61 KHVSFKKPHQ HSGEKLSVLQ DYIILPTITI FTVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEFB128 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 1,125 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 1,125 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- epididymal principal cells: 469 nCPM
- epididymal basal cells: 1.5 nCPM
- epididymal efferent duct ciliated cells: 1.3 nCPM
- vascular smooth muscle cells: 0.4 nCPM
- pericytes: 0.3 nCPM
- t-cells: 0.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0.4
- gnomAD missense Z
- -0.85
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- defense response to Gram-negative bacterium
- defense response to Gram-positive bacterium
- innate immune response
- killing of cells of another organism
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEFB128 as an antibody target. Whether an autoantibody or antibody against DEFB128 could matter depends on whether native DEFB128 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEFB128 is annotated as secreted, so native DEFB128 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label DEFB128 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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