DEFB125
Beta-defensin 125
Also known as: DB125_HUMAN, DEFB-25
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N687
- Gene
- DEFB125
- Ensembl
- ENSG00000178591
- Chromosome
- 20
- Canonical length
- 156 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Canonical amino-acid sequenceUniProt
156 residues, UniProt reviewed canonical sequence.
>Q8N687|DEFB125
1 MNILMLTFII CGLLTRVTKG SFEPQKCWKN NVGHCRRRCL DTERYILLCR NKLSCCISII
61 SHEYTRRPAF PVIHLEDITL DYSDVDSFTG SPVSMLNDLI TFDTTKFGET MTPETNTPET
121 TMPPSEATTP ETTMPPSETA TSETMPPPSQ TALTHNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEFB125 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 1.4 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 1.4 nTPM
- seminal vesicle: 1.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- cardiomyocytes: 6.8 nCPM
- adipocytes: 4.2 nCPM
- epicardial cells: 2.3 nCPM
- late spermatids: 1 nCPM
- epididymal principal cells: 0.7 nCPM
- early spermatids: 0.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.05
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEFB125 as an antibody target. Whether an autoantibody or antibody against DEFB125 could matter depends on whether native DEFB125 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEFB125 is annotated as secreted, so native DEFB125 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label DEFB125 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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