Seroatlas · Human Serome Atlas

DEFB112

Beta-defensin 112

Also known as: DB112_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q30KQ8
Gene
DEFB112
Canonical length
113 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for DEFB112 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q30KQ8|DEFB112
     1  MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR WKSCTAIGGR
    61  CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS VGTQEWYPKD SRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEFB112 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 23 nTPM
  • seminal vesicle: 0.4 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • epididymal principal cells: 107 nCPM
  • epididymal clear cells: 2 nCPM
  • epididymal basal cells: 1.5 nCPM
  • epididymal efferent duct ciliated cells: 0.4 nCPM
  • mast cells: 0.2 nCPM
  • t-cells: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.9
gnomAD pLI
0.02
gnomAD missense Z
-1.08
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEFB112 as an antibody target. Whether an autoantibody or antibody against DEFB112 could matter depends on whether native DEFB112 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEFB112 is annotated as secreted, so native DEFB112 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DEFB112 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DEFB112. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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