Seroatlas · Human Serome Atlas

DEFB109D

Beta-defensin 109D

Also known as: D109D_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DY26
Gene: DEFB109D
Canonical length: 87 aa

OverviewNCBI Gene

No narrative summary is available for DEFB109D in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>P0DY26|DEFB109D
     1  MRLHLLLLIL LLFKILLSPV RGDLGPVEGH CLNLSGVCRR DVCKVVEDQI GACRRRMKCC
    61  RAWWILMPIP TPLIMSDYQE PLKPKLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEFB109D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53

OntologyGO

Biological processes

defense response

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Beta/alpha-defensin, C-terminal

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEFB109D as an antibody target. Whether an autoantibody or antibody against DEFB109D could matter depends on whether native DEFB109D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEFB109D is annotated as secreted, so native DEFB109D circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DEFB109D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...