Seroatlas · Human Serome Atlas

DEFB109C

Beta-defensin 109C

Also known as: D109C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DY27
Gene: DEFB109C
Canonical length: 87 aa

OverviewNCBI Gene

No narrative summary is available for DEFB109C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>P0DY27|DEFB109C
     1  MRLHLLLLIL LLFSILLSPV RGGLGPAEGH CLNLFGVCRT DVCNIVEDQI GACRRRMKCC
    61  RAWWILMPIP TPLIMSDYQE PLKPNLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEFB109C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52

OntologyGO

Cellular components

extracellular region

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DEFB109C as an antibody target. Whether an autoantibody or antibody against DEFB109C could matter depends on whether native DEFB109C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DEFB109C is annotated as secreted, so native DEFB109C circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DEFB109C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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