DEFB109B
Beta-defensin 109B
Also known as: DB109_HUMAN, DEFB109P1B
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q30KR1
- Gene
- DEFB109B
- Ensembl
- ENSG00000206034
- Chromosome
- 8
- Canonical length
- 87 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
87 residues, UniProt reviewed canonical sequence.
>Q30KR1|DEFB109B
1 MRLHLLLLIL LLFSILLSPV RGGLGPAEGH CLNLFGVCRT DVCNIVEDQI GACRRRMKCC
61 RAWWILMPIP TPLIMSDYQE PLKPNLKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DEFB109B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 15 nTPM
- cerebral cortex: 1.9 nTPM
- thyroid gland: 1.8 nTPM
- retina: 1.7 nTPM
- skin: 1.5 nTPM
- lymph node: 0.9 nTPM
Single-cell type
- epicardial cells: 6.8 nCPM
- cardiomyocytes: 3 nCPM
- oligodendrocytes: 2.6 nCPM
- bergmann glia: 1.9 nCPM
- retinal amacrine cells: 1.4 nCPM
- oligodendrocyte progenitor cells: 1.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 46 nTPM
- cerebral cortex: 42 nTPM
- basal ganglia: 40 nTPM
- hypothalamus: 40 nTPM
- thalamus: 40 nTPM
- cerebellum: 38 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DEFB109B as an antibody target. Whether an autoantibody or antibody against DEFB109B could matter depends on whether native DEFB109B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DEFB109B is annotated as secreted, so native DEFB109B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label DEFB109B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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